在乳腺癌中逆侧下转移后的生存率
Ji-Jung Jung1, Jong-Ho Cheun2, Eunhye Kang1
1Department of surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Annals of surgical oncology
|May 2, 2024
概括
乳腺癌患者的逆侧支淋巴结转移 (CAM) 的生存结果不确定. 患有CAM和ipsilateral乳腺瘤复发 (IBTR) 的患者的生存率更好,这表明治愈治疗的潜在益处.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 转移研究 转移研究
背景情况:
- 乳腺癌患者的生存结果与逆侧支淋巴结转移 (CAM) 仍然不确定,尽管阶段IV分类.
- 超慢性CAM作为远程转移 (DM) 的第一个部位,需要进一步调查预后和治疗指导.
研究的目的:
- 为了研究乳腺癌患者的临床结果,有甲时性CAM.
- 提供对CAM的预后和治疗建议的见解.
主要方法:
- 乳腺癌患者的医疗记录的回顾性审查,其中甲时性CAM是第一个DM.
- 使用CAM患者与其他DM患者之间的倾向性得分匹配 (PSM) 来比较生存结果.
- 对乳腺瘤异侧复发 (IBTR) 对CAM患者存活时间的影响分析.
主要成果:
- 确定了40名乳腺癌患者,他们患有甲时性CAM.
- 在CAM患者中,估计的5年总生存率 (OS) 为39.6%,无进展生存率为39.4%.
- CAM患者的生存率略高于DM患者 (p=0.071),但与孤立的关节复发 (SCN) 的生存率相似 (p=0.509).
- 在PSM分析中,CAM和DM之间没有显著的生存差异 (HR1.47,p=0.124与HR1.19,p=0.542).
- 接受CAM和之前或同时接受IBTR (n=12) 的患者的生存率显著改善 (HR 0.28,p=0.024).
结论:
- 患有CAM的乳腺癌患者的存活率与DM患者的存活率相似,支持目前的第四阶段分类.
- 与IBTR相关的CAM表明了优越的生存结果.
- 患有IBTR的CAM患者的子组可能会从治疗意图治疗中受益.
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