心血管运动对癌症和癌症治疗相关心脏功能障碍的相关性
Simon Wernhart1, Tienush Rassaf2
1Department of Cardiology and Vascular Medicine, West German Heart- and Vascular Center, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. simon.wernhart@uk-essen.de.
Current heart failure reports
|May 2, 2024
概括
有氧运动训练 (AET) 改善心肺呼吸能力,并降低癌症患者的心血管风险. 然而,为了提高存活率和预防心脏功能障碍,最佳的AET疗法需要进一步研究.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 运动生理学 运动生理学
- 癌症的生存率 癌症的生存率
背景情况:
- 与癌症治疗相关的心脏功能障碍 (CTRCD) 对患者的生存构成重大威胁.
- 众所周知,有氧运动训练 (AET) 可以改善心肺呼吸能力 (CRF).
研究的目的:
- 审查AET对CTRCD相关的分子通路的影响.
- 讨论有关心脏瘤学运动干预的当前文献.
- 澄清特定的AET疗法与癌症存活率,心力衰竭发展和CTRCD减少之间的关系.
主要方法:
- 审查现有的心脏瘤运动试验.
- 对研究AET强度 (中等持续与高强度间歇训练) 的分析.
- 讨论通过运动调节的分子通路.
主要成果:
- AET,特别是中等强度的持续训练和高强度的间歇训练,有效地改善了CRF.
- AET减少了心血管疾病和心力衰竭住院治疗.
- AET对CTRCD和生存的最佳运动参数的长期影响仍然不清楚.
结论:
- 应考虑AET作为标准癌症治疗的辅助剂.
- 需要进一步的研究来确定最有效的AET持续时间和频率,以改善生存率和减轻CTRCD.
- 确定最佳的运动方案对于增强癌症患者的外周和中心适应是至关重要的.
更多相关视频
相关概念视频
Exercise and Cardiovascular Response
792
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
792
Exercise and Cardiac Output
1.0K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.0K
Pathophysiology of Cardiac Performance
644
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
644
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
Cardiovascular Drugs: Classification based on Therapeutic Indications
2.8K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.8K


