在患有精神障碍的人群中使用克洛扎,这些人经历了克洛扎的特定指示
Gregory E Simon1,2, Rebecca C Rossom3, Esti Iturralde4
1Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
The Journal of clinical psychiatry
|May 2, 2024
概括
对于需要这种药物的精神病患者,克洛扎的使用并不频繁. 黑人和西班牙裔个体经历自杀念头,自我伤害或治疗抵抗力的比例较低.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 克洛扎是治疗耐药精神分裂症和其他精神病障碍的关键药物.
- 特定的临床事件表明需要克洛扎宾,包括自我伤害,自杀念头和治疗抵抗.
- 了解克洛沙平的处方模式对于优化患者护理至关重要.
研究的目的:
- 调查克洛札在患有精神疾病的患者中使用率,这些患者有明确的使用指示.
- 根据患者的人口统计数据,识别克洛沙平启动的差异.
主要方法:
- 来自11个综合卫生系统 (2019-2019) 的电子健康记录的回顾性分析.
- 纳入标准:18岁以上的精神分裂症,精神分裂情绪障碍或其他精神病患者.
- 鉴定了经历自我伤害,自杀念头或因精神疾病住院/ED访问的患者,尽管接受了抗精神病治疗.
主要成果:
- 7,648名患者满足了至少一个指示事件的标准.
- 克洛沙平的启动率很低:自伤后为0.9%,自杀念头后为1.1%,治疗抵抗后为4.7%.
- 与有自杀念头的非西班牙裔白人患者相比,西班牙裔和非西班牙裔黑人患者中使用克洛扎宾的比例明显较低.
结论:
- 即使在患有精神疾病的患者中存在指示,克洛扎平的启动仍然不常见.
- 在克洛沙平的使用中存在显著的种族和民族差异,特别是在有自杀念头的患者中.
- 需要进行进一步的研究,以解决代表性不足的少数群体在克洛扎获取障碍.
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