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受体相互作用蛋白激酶-3 (RIPK3):一种新的生物标志物用于早产婴儿中死性肠球炎

Lirong Shen¹, Zuming Yang¹, Chuchu Gao¹

¹Department of Neonatology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China.

Pediatric surgery international

|May 2, 2024

概括

与受体相互作用的蛋白激酶-3 (RIPK3) 显示为在早产婴儿中诊断死亡性肠球炎 (NEC) 的生物标志物具有前途. 较高的RIPK3水平有助于评估疾病的严重程度,并指导康复后的养策略.

科学领域:

新生儿医学新生儿医学
生物标志物发现发现
胃肠病学胃肠病学

背景情况:

死性肠球炎 (NEC) 是早产婴儿的严重胃肠道紧急情况.
准确的诊断和NEC的严重程度评估对于患者的治疗结果至关重要.
需要新的生物标志物来改善NEC管理.

研究的目的:

评估受体相互作用蛋白激酶-3 (RIPK3) 的诊断,严重程度估计和预后作用,在患有NEC的早产婴儿中.
评估RIPK3与乳酸 (LA) 和C反应蛋白 (CRP) 等已知的标记物一起进行评估.

主要方法:

在108名早产婴儿中测量了RIPK3,LA和CRP的血水平 (24名NEC II阶段,18名NEC III阶段,66名对照).
使用接收器操作特征 (ROC) 曲线分析来评估诊断性能.
与疾病严重程度和完全肠道养 (FEFt) 的时间相关联的RIPK3水平.

主要成果:

在患有III期NEC的新生儿中,血RIPK3和LA水平升高.
在RIPK3,LA和CRP的合并ROC曲线下,NEC的诊断值达到0.925.
在RIPK3水平低于和高于20.06 ng/mL的婴儿之间,FefT的时间显著不同.

结论:

血RIPK3是NEC诊断和早产婴儿严重性评估的潜在生物标志物.
RIPK3水平可以为预后提供信息,并指导NEC恢复后的养策略.
需要进一步的研究,以在临床NEC管理协议中建立RIPK3.

关键词:

生物标志物生物标志物诊断值是一个诊断值.发生死性肠球炎.预测值是一个预测值.与受体相互作用的蛋白酶-3酶.

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