在临床前阿尔茨海默氏症疾病中量化假定视网膜结症
Swetha Ravichandran1, Peter J Snyder2,3, Jessica Alber3,4,5
1School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Investigative ophthalmology & visual science
|May 2, 2024
概括
视网膜质激活,神经炎症的标志物,在临床前阿尔茨海默病 (AD) 患者中更大. 这一发现表明,视网膜化可能作为阿尔茨海默病检测的早期生物标志物.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 神经科学是一个神经科学.
背景情况:
- 神经炎症是阿尔茨海默病 (AD) 病理学的关键因素.
- 视网膜质激活反映了在AD中看到的中枢神经系统变化.
- 光学连贯断层扫描 (OCT) 可以在体内可视化视网膜变化.
研究的目的:
- 为了调查视网膜滑膜病变的表面积是否在临床前AD患者和对照人群之间有所不同.
- 评估视网膜化作为早期AD检测生物标志物的潜力.
主要方法:
- 面对面的OCT成像被用于测量假定视网膜结晶症的表面积.
- 从76名参与者身上获得了光谱域OCT图像 (22名临床前AD,20名对照).
- 一般化的线性混合模型在组之间比较了视网膜结和RNFL厚度.
主要成果:
- 与对照组相比,在临床前AD组 (0.97 ± 0.55 mm2) 中,假定视网膜滑的表面积显著更大 (0.68 ± 0.40 mm2).
- 两组之间没有观察到视网膜神经纤维层 (RNFL) 厚度的显著差异.
结论:
- 在临床前阿尔茨海默病患者中,明显存在较大的假定视网膜结晶症.
- 视网膜结晶体有望成为AD相关神经炎症的潜在生物标志物.
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