脑下核刺激调节了帕金森病中心智的认知理论
Haoyun Xiao1,2, Liqin Lang3, Zheng Ye1
1Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
概括
在帕金森病 (PD) 患者中刺激体下核 (STN) 可能会损害认知思维理论 (ToM). 这表明STN因果关系影响认知ToM,可能会影响社会互动.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经学 神经学
背景情况:
- 思想理论 (ToM) 对社会互动至关重要,涉及认知和情感组成部分.
- 帕金森病 (PD) 与认知和情感ToM的干扰有关.
- 以前的研究主要集中在前额叶皮质在PD的ToM缺陷中的作用.
研究的目的:
- 为了研究体下核 (STN) 在心理理论 (ToM) 中的因果作用.
- 检查STN作为一个关键枢纽的参与与ToM相关的前端-基底结环.
主要方法:
- 34名特异性PD患者接受了Yoni任务,其中包括启动和关闭深度大脑刺激 (DBS).
- 约尼任务区分了ToM的认知和情感组成部分.
- 为三个STN亚区域计算活化组织 (VTA) 的体积.
主要成果:
- 集团级 DBS 对 ToM 推断成本的影响是微不足道的,可能是由于个体间的变化.
- 关联性VTA与认知推断成本变化正相关,而不是情感.
- 关联性STN的刺激对认知ToM产生了不利影响,特别是在广泛刺激或认知衰退的患者中.
结论:
- 关联性STN在帕金森病患者的认知ToM中起着因果作用.
- 刺激关联性STN可能会损害PD的认知ToM和社交互动能力.
- 这突出了STN在PD社会认知认知方面的关键功能.
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