缩短的aPTT值是否总是只能归因于分析前的问题?
Vanja Radišić Biljak1,2, Matea Tomas1, Ivana Lapić3,4
1Department of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia.
Diagnosis (Berlin, Germany)
|May 2, 2024
概括
缩短的激活部分血栓形成时间 (aPTT) 通常是由因子VIII (FVIII) 活性升高引起的,而不是分析前的问题. 这一发现甚至在没有炎症的情况下也是如此,这影响了常规的实验室参数解释.
科学领域:
- 临床化学 临床化学
- 血液学 血液学 血液学
- 凝血诊断 凝血诊断 凝血诊断
背景情况:
- 缩短的激活部分血栓形成时间 (aPTT) 可能源于各种分析前条件.
- 凝血因子VIII (FVIII) 是通过aPTT测量的内在途径的组成部分.
- 这项研究研究了FVIII活性升高与aPTT缩短之间的联系.
研究的目的:
- 检查FVIII活动升高与aPTT缩短之间的关联.
- 探索炎症对常规实验室参数的影响,包括aPTT和FVIII.
- 区分分析前的原因与导致aPTT缩短的生物学因素.
主要方法:
- 包括40名aPTT低于下基准值 (<23.0秒) 的患者.
- 从25名健康志愿者收集样本作为对照组.
- 在两组中测量白细胞计数,C反应蛋白,aPTT和FVIII值.
主要成果:
- 只有5%的aPTT缩短的患者样本有凝块;其余的没有凝块.
- 38名可评估患者中有26名 (68%) 显示FVIII活性升高 (>150%),中位数为194%.
- 多重回归分析确定FVIII活动是aPTT值的唯一独立预测因素 (p=0.001).
结论:
- 缩短的aPTT很少是由分析前的问题引起的.
- 升高的FVIII活性是缩短aPTT的一个重要原因.
- 这种升高会影响aPTT,无论炎症状态或炎症标志物是否存在.
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