早期低酸血症作为急性胰腺炎的预后标志物
Connor F Stewart1, Esther A Adeniran1, Dhiraj Yadav2
1From the Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Pancreas
|May 2, 2024
概括
低酸盐血清或低酸盐血清是急性胰腺炎 (AP) 患者的罕见标志物. 这种情况与急症监护室入院的增加,住院时间的延长和严重的AP有关,这表明其预后价值.
科学领域:
- 胃肠病学和肝病学
- 关键护理医学 关键护理医学
- 临床化学 临床化学
背景情况:
- 急性胰腺炎 (AP) 是住院的重要原因,需要确定预后标志物.
- 了解AP风险因素可以导致有针对性的治疗干预.
- 低血是潜在的,但被低估的,在AP的预后指标.
研究的目的:
- 调查急性胰腺炎患者的低酸血症和临床结果之间的关联.
- 确定医院住院早期测量的血清酸盐水平是否可以预测AP严重程度,ICU入院和住院时间.
主要方法:
- 对2012年至2021年期间入院的1526名AP患者的电子健康记录的回顾性审查.
- 在入院后48小时内分析血清酸盐水平.
- 使用多变量后勤和日志线性回归模型来评估与ICU入院,AP严重程度和停留时间的相关性.
主要成果:
- 只有33%的AP患者在入院后48小时内测量了血清酸盐.
- 低酸血症与更高的ICU入院几率 (AOR=4.57) 和中度至重度的AP (AOR=1.80) 有显著的关联.
- 低酸盐血症患者经历了更长的停留时间 (log-LOS=0.34).
结论:
- 血清酸盐测量在AP患者中不是常规进行的.
- 早期的低酸血症显示为急性胰腺炎不良结果的预后标志物具有显著的前景.
- 需要进一步的研究来探索在AP管理中监测血清酸盐的临床实用性.
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