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Updated: Jun 27, 2025

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种子微生物组对父亲编程的贡献
Justine Kilama1, Carl R Dahlen2, Lawrence P Reynolds2
1Department of Microbiological Sciences, North Dakota State University, NDSU Department 7520, Fargo, ND 58108-6050, USA.
Biology of reproduction
|May 2, 2024
概括
父亲因素,特别是精子微生物组,可能会影响后代的健康. 本综述探讨了精液微生物如何在传统表观遗传因素之外为父性编程做出贡献.
科学领域:
- 生殖生物学 生殖生物学
- 微生物组研究 微生物组研究
- 健康和疾病的发育起源 (DOHaD)
背景情况:
- 传统上,DOHaD领域强调母亲对后代健康的影响.
- 新兴研究强调了父系因素的潜在作用,包括精子微生物组.
- 精液微生物在历史上被认为是致病的,但现在被认为是一个多样化的共生社区.
研究的目的:
- 对人类和动物的精子微生物群的当前知识进行审查.
- 讨论精液微生物群在父亲对后代健康的规划中的参与.
- 通过精子微生物群提出并探索通过精子微生物群传播父亲影响机制.
主要方法:
- 关于精液微生物群的现有研究的文献综述.
- 关于交配期间微生物传播的证据综合.
- 讨论通过精子微生物组进行父性编程的拟议机制.
主要成果:
- 种子微生物组包括一个多样化的共生微生物社区.
- 精液微生物可以传播到女性生殖道,可能会影响生育能力和胚胎发育.
- 有证据表明,精子微生物群在父亲对后代健康的规划中起着作用.
结论:
- 种子微生物组代表了父性编程的新途径.
- 了解基于精子微生物组的父性编程扩展到表观遗传修饰,氧化应激和细胞因子之外.
- 需要进一步的研究,以充分阐明精子微生物组介导的父性影响的机制和影响.
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