关于子宫内膜异位症疼痛随机对照试验的报告质量和旋转:基于CONSORT扩展摘要的方法研究
Hoda Shirafkan1, David Moher2, Parvaneh Mirabi3
1Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
PloS one
|May 2, 2024
概括
对子宫内膜异位症的骨盆疼痛随机对照试验摘要的报告质量很差,超过一半的结果显示出误导性结果 (旋转),特别是当初级终点不显著时. 这突出了妇科治疗科学传播的问题.
科学领域:
- 产科和妇科 产科和妇科
- 临床试验方法论 临床试验方法论
- 科学沟通科学沟通
背景情况:
- 随机对照试验 (RCT) 摘要的报告质量对于基于证据的实践至关重要.
- 子宫内膜异位症的骨盆疼痛研究摘要需要清晰准确的报告来指导临床决策.
- 旋转,或误导性报告,可以扭曲治疗的感知有效性.
研究的目的:
- 评估关于子宫内膜异位症骨盆疼痛的RCT摘要的报告质量.
- 为了确定这些摘要中旋转的流行程度和特征.
- 确定影响报告质量和流程的因素.
主要方法:
- 在PubMed和Scopus系统搜索关于子宫内膜异位症骨盆疼痛的RCT摘要 (2010-2023).
- 使用CONSORT简报声明 (CONSORT-A) 评估报告质量.
- 评估结果和结论中的旋转,并使用回归模型进行统计分析.
主要成果:
- 分析了47个RCT摘要;报告质量不理想,CONSORT-A指南的遵守程度不佳.
- 只有三个项目 (目标,干预,结论) 得到了良好报告;没有准确的数据报告.
- 旋转是普遍存在的,特别是在没有显著结果的研究中 (66.66%的那些没有显著结果的人有旋转).
- 从2010年到2023年,回旋强度增加了,38.29%的摘要在结果和结论中都显示了回旋.
结论:
- 在RCT摘要中观察到对子宫内膜异位症的骨盆疼痛的CONSORT-A报告标准的不充分遵守.
- 脊柱是一个重要的问题,在妇科文献中经常与非显著的初级终点相关.
- 改善报告和减少旋转是必要的,以便在这个领域进行准确的科学沟通.
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