在患有自闭症遗传责任的婴儿中,杏仁体和视觉,突出区域之间的非典型功能连接性
Janelle Liu1,2,3, Jessica B Girault4,5, Tomoyuki Nishino6
1Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.
Cerebral cortex (New York, N.Y. : 1991)
|May 2, 2024
概括
患有自闭症谱系障碍 (ASD) 的可能性很高的婴儿表现出不同的杏仁体连接性,特别是在视觉区域. 在早期发育过程中,这种改变的大脑连接性可能会影响行为和沟通技巧.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 遗传学 是一个遗传学.
背景情况:
- 杏仁体对于社会情绪处理至关重要,在后来被诊断为自闭症谱系障碍 (ASD) 的婴儿中会扩大.
- 早期非典型的杏仁体发育可能会导致婴儿期的功能后果.
研究的目的:
- 为了研究12个月大的婴儿桃体功能连接的差异,高概率 (HL) 的ASD与低概率 (LL).
- 为了探索桃体与视觉皮层的连接性,给出了在ASD中异常视觉电路发展的先前证据.
主要方法:
- 在12个月大的婴儿中,对左桃体和右桃体进行基于种子的连接性分析.
- 在HL婴儿 (自闭症较大的兄弟姐妹) 和LL婴儿之间的比较.
主要成果:
- 在HL的婴儿中,右桃体与左视觉皮层之间的连接性较弱.
- 在HL婴儿中,左桃体和右前带肌之间也观察到减少了连接性.
- 杏仁体与视觉皮层的连接性与HL婴儿的运动和沟通能力相关.
结论:
- 杏仁体和视觉区域之间的异常功能连接存在于具有ASD遗传责任的婴儿中.
- 这些早期的连接性差异可能是适应性行为和发育观察到的变异的基础.
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