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Updated: Jun 27, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

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一个工作流程,以改进对交叉链接质谱数据的分析,将并行积累-串行碎片化与MeroX和天际线集成

Juan Camilo Rojas Echeverri1,2, Frank Hause1,2,3, Claudio Iacobucci1,2,4

  • 1Department of Pharmaceutical Chemistry and Bioanalytics, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany.

Analytical chemistry
|May 2, 2024
PubMed
概括

这项研究增强了在timsTOF仪器上使用并行积累串行碎片 (PASEF) 的交叉连接质谱 (XL-MS). 新的以为中心的工作流改善了复杂混合物中交联的识别.

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