种族解释了全血胺二酸盐度的巨大差异
1Department of Psychiatry & Behavioral Sciences, Stanford University, School of Medicine, Stanford, CA 94305, USA; Neuroscience Program, SRI International, Menlo Park, CA, 94025, USA.
Nutrition research (New York, N.Y.)
|May 2, 2024
概括
全血胺二酸盐 (TDP) 度在酒精使用障碍 (AUD),艾滋病毒或健康对照患者之间没有差异. 然而,黑人个体的TDP水平比白人个体低,无论诊断如何,这表明在胺状况上存在种族差异.
科学领域:
- 营养神经科学 营养神经科学
- 临床生物化学 临床生物化学
- 公共卫生 公共卫生
背景情况:
- 胺 (维生素B1) 缺乏是酒精使用障碍 (AUD) 和艾滋病毒的一个问题.
- 之前的评估依赖于酶活性,对艾滋病病毒中的二胺二酸盐 (TDP) 的数据有限,对AUD.有模两可的发现.
- 周围神经病变是一种已知的并发症,与胺缺乏有关.
研究的目的:
- 为了研究与健康对照组相比,AUD和HIV患者的全血胺二酸盐 (TDP) 度.
- 为了确定TDP度是否与外围神经病变有关.
- 探索种族对这些队伍中的TDP水平的影响.
主要方法:
- 横截面研究分析了全血TDP度在170AUD,130艾滋病毒,和100健康的对照参与者.
- 使用两点歧视测试对外围神经病变的评估.
- 多重回归分析,以评估种族和诊断对TDP水平的影响.
主要成果:
- 在AUD,HIV和健康对照组之间没有观察到全血TDP度的显著差异 (P = .6141).
- 与白人相比,黑人个体的TDP度明显较低 (P < .0001),无论他们的诊断组如何.
- 周围神经病变在AUD和HIV组中更为普遍 (P < .0001),但与TDP度没有关联.
结论:
- 种族,而不是AUD或HIV诊断,是与较低全血TDP度相关的重要因素,黑人个体的风险更高.
- 这种TDP水平的种族差异的临床意义和潜在机制需要进一步调查.
- 在这些群体中,外围神经病变似乎与测量全血TDP水平无关.
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