慢性鼻炎的非抗生素抗菌剂:叙述性综述
Joao Vitor Bizinoto Caetano1, Fabiana Cardoso Pereira Valera1, Wilma T Anselmo-Lima1
1Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Ribeirão Preto, SP, Brazil.
Brazilian journal of otorhinolaryngology
|May 2, 2024
概括
在研究成人慢性鼻炎 (CRS) 的非抗生素抗微生物药物方面,本次审查强调了西利托尔,婴儿洗发水和波维作为有希望的替代品. 需要进一步的研究才能对这些新的CRS治疗方法做出明确的建议.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性鼻炎 (CRS) 的治疗通常依赖于抗生素,这引发了人们对耐药性和副作用的担忧.
- 其他非抗生素抗菌剂正在研究其在CRS治疗中的潜力.
- 目前的文献缺乏对这些新兴疗法的全面审查.
研究的目的:
- 探索和审查其他非抗生素抗微生物药物用于管理成人患者的CRS.
- 根据目前的证据,评估各种非抗生素治疗的疗效和安全性.
- 提供对传统抗生素之外的CRS管理潜在未来方向的见解.
主要方法:
- 对2003年至2022年间发表的研究进行了叙述性审查.
- 搜索的数据库包括PubMed和EMBASE,遵循EPOS 2020对代理选择的指南.
- 包括的研究是随机对照试验和队列研究;审查和体外实验被排除在外.
主要成果:
- 克西利托尔在CRS患者中显著减轻了症状,超过了盐水灌.
- 婴儿洗发水灌改善了鼻膜清除和术后结果.
- 曼努卡蜂蜜,合银,波维和菌体显示出多种但潜在的益处,尽管需要进一步的研究才能获得确的证据.
结论:
- 非抗生素药物,如西利托,婴儿洗发水和波维对CRS症状和内镜评分的改善有希望.
- 有限的研究需要进一步的研究,以获得最终的建议和安全评估.
- 对CRS管理的综合方法至关重要,特别是在非传染病例中,为确诊的细菌感染保留抗生素.
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