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提高维生素D的生物可访问性:通过婴儿体外消化模型揭示大豆蛋白分离物和维生素D结合中的疏水性相互作用

Jia-Rong Huang¹, Jing-Ru Song¹, Wan-Shuang Cai¹

¹SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Liaoning Province Key Laboratory for Marine Food Science and Technology, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.

|May 2, 2024

概括

这项研究设计了大豆蛋白分离纳米颗粒来增强婴儿营养中的维生素D3 (VD3) 吸收. 优化的纳米粒子在模拟消化过程中显著提高了VD3的生物可访问性和生物可用性.

科学领域:

食品科学与技术食品科学与技术
营养生物化学营养生物化学
在食品中纳米技术.

背景情况:

优化营养吸收,特别是维生素D3 (VD3),对于婴儿营养至关重要.
大豆蛋白分离物 (SPI) 是营养包装的潜在载体.
开发有效的VD3输送系统对于婴儿健康至关重要.

研究的目的:

通过使用动态高压微流化 (DHPM) 来设计大豆蛋白分离-维生素D3 (SPI-VD3) 纳米颗粒.
评估SPI-VD3纳米粒子的物理化学特性和模拟婴儿消化性能.
评估DHPM对VD3生物可访问性和生物可用性的影响.

主要方法:

动态高压微流化 (DHPM) 应用于SPI用于纳米粒子形成.
纳米颗粒结合亲和力和表面疏水性的表征.
模拟婴儿消化模型,以评估VD3的生物可访问性和化动态.
分子模拟以阐明纳米粒子行为.

主要成果:

在80MPa的DHPM处理中,产生了SPI-VD3纳米粒子,具有高结合亲和力 (Ka = 0.166 × 10^5 L·mol−1) 和表面疏水性 (H0 = 3494).
在模拟婴儿消化过程中,80 MPa DHPM处理的纳米颗粒显示出74.4%的VD3生物可访问性.
胆盐在VD3重新封装中发挥了关键作用,防止结晶并增强吸收.

结论:

通过DHPM设计的SPI-VD3纳米颗粒显示出在婴儿配方奶粉中改善VD3吸收的巨大潜力.
DHPM增强了纳米颗粒的完整性和疏水性,从而增加了VD3的生物可用性.
这些发现为开发先进的婴儿营养配方提供了宝贵的见解.

关键词:

动态高压微流体化技术强化酸奶的强化酸奶水性水性水性婴儿体外消化婴儿体外消化维生素D ((3) 的生物可访问性

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