感应贴片用于皮肤衍生生物流体中的生物标志物识别
Chen Wei1, Danni Fu1, Tianyue Ma1
1Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China.
Biosensors & bioelectronics
|May 2, 2024
概括
非侵入性皮肤贴片提供了一个简单的,安全的替代品,用于诊断疾病的血液测试. 这些可穿戴设备从汗水,间歇性液体和伤口排泄物中收集生物标记物,用于护理点测试.
科学领域:
- 生物医学工程 生物医学工程
- 可穿戴技术可穿戴技术
- 诊断工具 诊断工具
背景情况:
- 传统的疾病诊断依赖于侵入性血液或血清采样.
- 侵袭性方法存在感染风险,需要专门的设备和人员.
- 当前的诊断过程可能导致结果延迟,阻碍及时治疗.
研究的目的:
- 审查用于疾病诊断的非侵入性基于皮肤的生物标志物检测贴片.
- 探索通过皮肤介导的生物流体采集在临床检测 (POCT) 的优势.
- 总结皮肤生物标志物的贴片类型,制造和检测策略.
主要方法:
- 审查关于皮肤生物标志物检测贴片的现有文献.
- 根据生物流体来源对贴片的分类:汗水,间歇性流体 (ISF) 和伤口排泄物.
- 对可穿戴和透皮贴片的制造和检测方法的分析.
主要成果:
- 皮肤贴片 (汗水,MN,伤口) 允许进行非侵入性或最小侵入性的生物流体采集.
- 这些贴片提供了诸如简单的制造,良好的透皮性质和易于使用等优点.
- 不同的贴片类型适用于从皮肤中收集不同的生物标志物.
结论:
- 基于皮肤的生物标志物检测贴片代表了早期疾病诊断的重大进展.
- 需要进一步的研究来应对临床应用和检测准确性的挑战.
- 这些贴片有望提高护理点诊断的可访问性和效率.
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