在丹麦登记处诊断的饮食障碍 - 发病率,流行率,死亡率和多基因风险
Janne Tidselbak Larsen1, Zeynep Yilmaz2, Cynthia M Bulik3
1National Centre for Register-based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
Psychiatry research
|May 2, 2024
概括
这项研究研究了丹麦的饮食障碍患病率和死亡率. 神经性厌食症 (AN) 在具有特定遗传倾向的个体中最常见,被诊断患有饮食障碍的男性面临着明显更高的死亡率.
科学领域:
- 精神病学和流行病学 精神病学和流行病学
- 遗传学和公共卫生
背景情况:
- 饮食障碍是严重的精神疾病,死亡率高,但与其他精神疾病相比,研究范围有限.
- 现有的流行病学研究往往提供相对死亡率的指标,这些指标很难解释,并且在实践中具有有限的实用性.
- 了解饮食障碍的发病率,流行率和死亡率对于公共卫生倡议至关重要.
研究的目的:
- 确定在丹麦被诊断为神经性厌食症 (AN),神经性食欲症和其他未指明的饮食障碍 (EDNOS) 的发生率和流行率.
- 估计与这些饮食障碍相关的所有原因和特定原因死亡率的相对和绝对指标.
- 调查AN多基因分数,体脂百分比和体质指数对AN患病率和严重性的预测价值.
主要方法:
- 来自丹麦医院登记册的诊断饮食障碍和死亡率数据分析了全国人口的1,667,374个人.
- 估计发病率,流行率以及相对和绝对死亡率 (全因和因特定) 的指标.
- 利用基因信息的病例-队列样本来评估AN流行和严重程度的多基因得分预测.
主要成果:
- 精神性厌食症 (AN) 患病率在具有高AN多基因分数和低身体脂肪百分比/体重指数多基因分数的个体中最高.
- 尽管诊断率较低,但被诊断患有饮食障碍的男性的死亡率明显增加.
- 该研究提供了关于饮食障碍及其相关死亡率在大量人口中的综合流行病学数据.
结论:
- 饮食障碍是一个重要的公共卫生问题,具有很大的死亡风险,特别是在男性中.
- 遗传因素,包括AN的多基因分数和代谢特征,在AN的流行和严重性方面发挥着作用.
- 这项研究强调了需要增加注意力和更好地了解饮食障碍及其长期后果.
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