肠道胆酸吸收增加有助于与年龄相关的认知障碍
Zhenxing Ren1, Ling Zhao2, Mingliang Zhao1
1Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiaotong University School of Medicine, Shanghai 200233, China.
Cell reports. Medicine
|May 2, 2024
概括
胆酸和氨的升高与老年人和动物的认知能力下降有关. 向肠道胆酸吸收可能为与年龄相关的认知障碍提供了一个新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 老年人的认知障碍越来越令人担忧,通常与代谢失调有关.
- 在衰老和神经退行性疾病中观察到胆酸 (BA) 代谢的改变.
研究的目的:
- 调查胆酸代谢与衰老中的认知障碍之间的关系.
- 探索状状酸运输体 (ASBT) 在认知功能中的作用.
- 评估调节肠道胆酸吸收对认知衰退的治疗潜力.
主要方法:
- 测量了老年人和老年动物的合初级胆汁酸 (CPBA) 和氨的血清和大脑水平.
- 在动物中评估海马突触完整性和认知表现.
- 利用体外模型研究CPBA和氨对突触损失的影响.
- 在动物中使用ASBT激活剂/抑制剂和注射胆固醇胺来操纵肠道BA运输.
主要成果:
- 在认知障碍和衰老的个人和动物中发现血清CPBA和氨的升高,女性的水平更高.
- 增加ASBT表达,海马突触损失和脑CPBA/氨水平升高与动物认知能力下降相关.
- 在体外实验证实,陶罗霍酸和氨诱导突触损失.
- 调节ASBT和给予胆固醇胺影响了大脑的CPBA/氨水平,并逆转了老年小鼠的认知缺陷.
结论:
- 结合初级胆汁酸和氨在与年龄相关的认知障碍中起着重要作用.
- 肠道胆汁酸的吸收是缓解认知衰退的可行的治疗点.
- 针对ASBT或使用胆酸分离剂显示出治疗认知障碍的前景.
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