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渐进增强的光动力学疗法和增强的化疗与连续释放药物的恶性瘤作斗争

Yibo Yang¹, Xin Zhang¹, Zhimin Bai¹

¹Nano-Biotechnology Key Lab of Hebei Province, Hebei Key Laboratory of Applied Chemistry, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, Hebei, Province 066000, People's Republic of China.

Biomedical materials (Bristol, England)

|May 2, 2024

概括

这项研究引入了一种用于顺序药物输送的新型纳米平台,通过克服瘤缺氧和药物耐药性来增强癌症治疗. 该系统结合了光动力学治疗和化疗,以改善结果.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

恶性瘤治疗面临瘤缺氧限制光动力学治疗 (PDT) 疗效的挑战.
化学疗法耐药性是由于药物排泄,如p-glycoprotein (p-gp) 引起的.

研究的目的:

开发一种基于半孔的纳米平台 (MSN@PDA) 用于连续的药物输送.
通过多药加载系统,通过将PDT和化疗结合起来来增强恶性瘤治疗.

主要方法:

合成的半孔性纳米颗粒 (MSN) 并涂上聚多巴胺 (PDA).
在MSN@PDA平台上,对角加载了多克索鲁比辛 (DOX),绿色 (ICG) 和二氧化 (MnO2).
实现了连续的药物释放,用于联合光动力学和化疗效应.

主要成果:

纳米平台 (DMPIM) 从MnO2产生氧气,缓解瘤缺氧并增强PDT.
印ocyanine绿色 (ICG) 产生反应性氧物种,促进药物释放和抑制p-gp.
多克索鲁比 (DOX) 释放延迟了约8小时,使PDT后的顺序化疗成为可能.

结论:

开发的纳米平台可以实现连续的药物释放和多模式组合疗法.
这种方法显示出通过克服耐药性和缺氧来治疗恶性瘤的显著治疗潜力.

关键词:

化学疗法化疗化疗光动力学疗法是一种光动力学疗法.有活性氧物种的反应性氧物种.连续释放的顺序释放.

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