在患有间歇性肺病的患者中,FVC下降的比例和预测因素
Maeve G Macmurdo1, Xinge Ji2, Pratik Pimple3
1Respiratory Institute, Cleveland Clinic, United States.
Respiratory medicine
|May 2, 2024
概括
渐进性肺纤维化 (PPF) 影响了许多患有间歇性肺病 (ILD) 的患者. 类固醇治疗是发展PPF的一个危险因素,强调了对可修改因素的进一步研究的需要.
科学领域:
- 肺部病理学 肺部病理学
- 纤维化间歇性肺病 纤维化间歇性肺病
- 临床流行病学临床流行病学
背景情况:
- 在患有间歇性肺病 (ILD) 的患者中,进展性肺纤维化 (PPF) 的发展和风险因素尚不清楚.
- 确定PPF的预测因素对于患者管理和治疗策略至关重要.
研究的目的:
- 在一大批ILD患者中调查与患PPF风险增加相关的因素.
- 为了比较不同标准 (PFILD和ATS PPF) 在评估疾病进展中的实用性.
主要方法:
- 对5934名在转诊中心被诊断患有ILD的患者进行了回顾性观察性研究.
- 根据PFILD和ATS PPF标准,使用强迫生命能力 (FVC) 变化估计了进展风险.
- 确定了进展的临床预测因素.
主要成果:
- 在24个月的累积进展发生率很大,有33.1% (PFILD) 和37.9% (PPF) 的患者进展.
- 类固醇治疗与逐渐纤维化的风险增加显著相关 (HR 1.46).
- 根据基础的ILD诊断,观察到进展率的差异.
结论:
- 在诊断后24个月内,无论使用什么标准,在ILD患者中观察到高累积发病率的进展.
- 虽然PFILD和PPF标准显示了一些差异,但两者都表明了显著的进展.
- 需要进行进一步的研究,以确定可改变的ILD中渐进性纤维化风险因素.
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