下肢周围动脉疾病首次住院后死亡风险的性别差异
Cindy P Porras1, Annemarijn R de Boer2, Yvonne Koop2
1Department of Nephrology and Hypertension, University Medical Centre Utrecht, Utrecht, the Netherlands; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, the Netherlands.
概括
周围动脉疾病 (PAD) 的五年死亡风险增加,女性的死亡率低于男性. 患有PAD患者的死亡率高于一般人群.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 下肢外周动脉疾病 (PAD) 是不良心血管和四肢事件的重要危险因素,以及全因死亡率.
- 研究住院PAD患者死亡风险的性别差异对于了解疾病预后至关重要.
研究的目的:
- 为了比较女性和男性之间的死亡风险,首次住院治疗下肢PAD.
- 分析随着时间的推移死亡率的趋势,并将其与一般人口进行比较.
主要方法:
- 分析了2007-2018年间因首次下肢PAD入院的三组患者队列.
- 在28天,1年和5年后的死亡率被计算出来,并使用考克斯的比例危险模型进行性别比较,并对混因素进行了调整.
- 标准化死亡率 (SMRs) 用于将PAD患者的死亡率与一般人口进行比较.
主要成果:
- 超过31,000名患者被纳入三个队列,男性占个人60%以上.
- 虽然28天和一年的死亡率保持稳定,但在2011-2014年的两性队列中,五年死亡率增加.
- 与男性相比,女性的五年死亡风险较低 (危险比:0.88-0.89).
结论:
- 尽管短期死亡率稳定,但与下肢PAD相关的五年死亡风险增加了.
- 患有下肢PAD的女性比男性的五年死亡风险更低.
- 与一般人群相比,患有下肢PAD的个体继续面临不利的长期结果.
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