功能化脂质体作为结肠癌治疗的潜在药物递送系统:系统性审查
Eskandar Moghimipour1, Somayeh Handali2
1Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
概括
向性脂质体对改善药物输送和减少副作用的结肠癌治疗有希望. 这一系统性审查强调了与传统方法相比,它们在增强抗癌疗效方面的潜力.
科学领域:
- 在瘤学瘤学.
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 结肠癌是全球主要的死亡原因,目前的化疗和放射治疗等治疗方法会引起显著的副作用.
- 向的纳米载体,特别是脂质体,因其选择性地将抗癌药物输送到瘤细胞的能力而受到关注.
- 活性向配体增强结肠癌细胞的脂质体特异性,改善治疗结果.
研究的目的:
- 在结肠癌治疗中系统地审查各种配体的使用,以积极向脂质体.
- 与传统疗法相比,评估向脂质体的疗效和安全性.
- 评估向脂质体在结肠癌中改善药物输送的潜力.
主要方法:
- 2012年至2022年间发表的英语文章的系统审查.
- 在科学直接,PubMed和谷歌学者数据库中进行的搜索.
- 包括标准适用于最初识别的26,256篇文章,其中19篇被选择进行分析.
主要成果:
- 向性脂质体在体外和体内表现出抗癌药物对结肠癌细胞的有效性增加.
- 与免费药物和非向脂质体相比,针对性脂质体的副作用减少.
- 用于主动准,使用了叶酸,转激素,阿巴,氨酸和cRGD等联体.
结论:
- 向性脂质体是改善结肠癌治疗的有希望的策略.
- 积极向显著改善药物输送和治疗疗效,同时最大限度地减少不良影响.
- 本综述提供了利用向脂质体技术推进结肠癌治疗的证据.
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