氧化生物标志物和食酸盐补充后的生理结果之间的关系
Chenguang Wei1, Anni Vanhatalo1, Matthew I Black1
1University of Exeter Medical School, Faculty of Health and Life Sciences, University of Exeter, St Luke's campus, Exeter, EX81JS, UK.
Nitric oxide : biology and chemistry
|May 2, 2024
概括
在甜菜汁中发现的酸盐食补充剂可以降低血压并增强肌肉功能. 整个血液中的S-nitrosothiols和骨肌肉中的酸盐水平是这些影响的关键生物标志物.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 心血管科学 心血管科学
背景情况:
- 饮食中酸盐 (NO3-) 补充剂可提高氧化 (NO) 的生物可用性,影响血压 (BP) 和肌肉功能.
- 血亚酸盐 (NO2-) 是一种常见的生物标志物,但它与酸盐在饮食中的生理影响的相关性需要澄清.
- 该研究调查了不同生物样本中的各种NO生物标志物 (NO3-,NO2-,S-nitrosothiols [RSNOs]).
研究的目的:
- 确定哪些氧化 (NO) 生物标志物与急性和慢性酸盐 (NO3-) 食补充剂的生理效应相关.
- 为了比较NO3丰富的甜菜汁 (BR) 与安慰剂 (PL) 在血压和肌肉收缩功能的疗效.
- 为了确定可靠的生物标志物,以确定NO的生物可用性,通过饮食摄入NO3-.
主要方法:
- 一个随机,双盲,交叉研究,涉及12名参与者.
- 参与者服用了富含酸盐的甜菜汁 (BR) 和酸盐贫乏的安慰剂 (PL),无论是急性还是慢性 (两周).
- 测量包括静止血压 (BP),肌肉收缩功能 (扭矩发展速度),以及血,全血,红细胞和骨肌肉中的各种NO生物标志物.
主要成果:
- 与PL相比,急性BR补充剂显著降低了透静血压.
- 慢性BR补充剂显著提高了膝盖延伸器的扭矩发展速度.
- 全血S-尼特罗斯醇 (RSNO) 与急性摄入后较低的透静血压相关.
- 骨肌肉酸盐 (NO3-) 与慢性摄入后改善的肌肉收缩功能相关.
结论:
- 整体血液中的S-nitrosothiols (RSNOs) 和骨肌肉酸盐 (NO3-) 是评估氧化 (NO) 生物可用性的相关生物标志物.
- 这些生物标志物与酸盐 (NO3-) 食补充剂降血压和增强肌肉功能的作用有关.
- 这些发现强调了考虑不同生物组的特定生物标志物的重要性,以了解酸盐在饮食中的生理影响.
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