类风湿性关节炎疾病活动与患者报告的与健康相关的生活质量之间的相关性:一个横截面研究
JunChao Feng1,2,3, Lingjia Yu4, Yingying Fang4
1Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
BMJ open
|May 2, 2024
概括
类风湿性关节炎 (RA) 显著影响患者的与健康相关的生活质量 (HRQoL). 较高的疾病活性与降低的HRQoL相关,突出显示了与临床标志物一起测量患者福祉的重要性.
科学领域:
- 类风湿病学 类风湿病学
- 健康 结果 研究 研究 结果
- 生活质量研究 生命质量研究
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,影响关节,并可能导致严重的残疾.
- 患者报告的结果,特别是与健康相关的生活质量 (HRQoL),对于全面了解RA的影响至关重要.
- 评估临床疾病活动和HRQoL之间的相关性对于全面的患者管理至关重要.
研究的目的:
- 为了全面评估类风湿性关节炎 (RA) 患者的HRQoL在不同疾病活动水平.
- 评估已建立的临床活动测量和验证的HRQoL仪器之间的相关性.
- 确定RA对HRQoL身体,心理和社会方面的影响.
主要方法:
- 这是一项涉及314名RA患者的横截面观察性研究.
- 使用了通用的HRQoL仪器 (EQ-5D-5L,SF-12,AQoL-4D) 和一种特定疾病的仪器 (HAQ-DI).
- 使用疾病活动评分28-红细胞沉积率 (DAS28-ESR) 评估临床疾病活动,并采用多变量线性和斯皮尔曼相关性分析.
主要成果:
- 与缓解期患者相比,中度至高度的RA疾病活动患者报告HRQoL得分明显较低 (p<0.05).
- 增加的疾病活性与更高的HAQ-DI得分相关,表明功能障碍更大.
- 所有评估的仪器都显示了与RA活动的中度到强度的相关性,疾病特定的HAQ-DI显示了最高的相关性 (我认为RSS=0.500.65).
结论:
- 类风湿性关节炎严重损害了患者的身体和心理社会功能,影响了他们的整体HRQoL.
- 临床疾病活动和HRQoL之间存在强烈的相关性,这表明HRQoL测量是有价值的临床补充.
- 建议使用EQ-5D-5L作为适合于测量RA患者HRQoL的通用仪器.
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