CCK+ 内神经元有助于在前临床前额叶皮层中诱发泰拉马斯的前进抑制
Aichurok Kamalova1, Kasra Manoocheri1, Xingchen Liu1
1Center for Neural Science, New York University, New York, New York 10003.
概括
在前皮质中,胆囊氨酸表达 (CCK+) 内神经元调解着质引起的抑制,与表达帕瓦氨酸 (PV+) 的细胞不同. 大麻素受体调节这种CCK+内部神经元通路,影响中间前额叶皮层的通信.
科学领域:
- 神经科学是一个神经科学.
- 细胞神经科学 细胞神经科学
- 系统神经科学 系统神经科学
背景情况:
- 中间前额叶皮层 (PFC) 内神经元调节神经活动,影响行为.
- 帕瓦胺表达性 (PV+) 内神经元在许多皮层区域中介导着 thalamus 唤起的抑制.
- 在前皮层 (PL) 皮层3层中,PV+内部神经元稀缺,这表明了其他抑制机制.
研究的目的:
- 在PL皮层中识别介导中脊椎 (MD) 丘脑引起的抑制的内部神经元.
- 为了研究胆囊托基宁表达 (CCK+) 内神经元在PL中的作用.
- 为了探索MD-PL途径抑制的大麻素受体调节.
主要方法:
- 切片生理学 切片生理学
- 视觉遗传学 视觉遗传学
- 交叉的遗传工具 交叉的遗传工具
- 对两性小鼠的研究.
主要成果:
- 快速升 (fs) 和非快速升 (nfs) 的CCK+内部神经元在PL层3中丰富.
- MD输入优先激发fs-CCK+内部神经元.
- CCK+内部神经元为金字塔细胞提供周体抑制,由大麻素1受体 (CB1R) 调节.
- 由MD引起的前抑制对CB1R调制敏感.
结论:
- CCK+ 内神经元是PL皮层中MD引起的抑制的关键媒介.
- 通过CB1R进行大麻素信号传递,通过CCK+内部神经元调节MD-PFC通信.
- 这揭示了大麻素对认知和情绪处理的影响的新途径.
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