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Updated: Jun 27, 2025

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癌症治疗的MDM2抑制剂:过去,现在和未来

Wei Wang1, Najah Albadari2, Yi Du2

  • 1Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy (W.W., Y.D., J.F.F., H.T.S., R.Z.), Drug Discovery Institute (W.W., R.Z.), Stem Cell Center, Department of Biology and Biochemistry (W.X., F.M.), University of Houston, Houston, Texas; College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee (N.A., W.L.); and Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas (J.Z.) wwang4@central.uh.edu rzhang27@central.uh.edu.

Pharmacological reviews
|May 2, 2024
PubMed
概括

针对MDM2 (老鼠双分钟2同类物) 通过诱导蛋白质降解,显示出对癌症治疗的希望. 研究正在探索MDM2抑制剂,包括与免疫治疗的结合,以克服治疗耐药性并改善患者的治疗结果.

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