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Updated: Jun 27, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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细胞毒性sigma-2连接体通过胆固醇诱导的ER压力触发癌细胞死亡

Rony Takchi1, Bethany C Prudner2, Qingqing Gong1

  • 1Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Cell death & disease
|May 2, 2024
PubMed
概括

西格玛-2-联结体 (S2L) 通过积累胆固醇导致癌细胞死亡,从而导致ER压力. 将S2L与simvastatin或ER压力诱导剂结合使用可能会增强抗瘤功效.

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Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro13:20

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