相关实验视频

Updated: Jun 27, 2025

Setting a Successful Sorting for Extracellular Vesicle Isolation

Setting a Successful Sorting for Extracellular Vesicle Isolation

Published on: October 11, 2024

介酶干细胞衍生的细胞外囊泡:一种调节剂和载体,用于向与骨相关的疾病

Jiandong Tang¹, Xiangyu Wang¹, Xu Lin¹

¹Orthopaedics Center, Zigong Fourth People's Hospital, Tan mu lin Street 19#, Zigong, 643099, Sichuan Province, China.

Cell death discovery

|May 2, 2024

概括

介质干细胞衍生的细胞外囊泡 (MSC-EVs) 显示出治疗骨疾病的前景. 这些天然纳米粒子有效地输送治疗分子,并且可以被设计为有针对性的输送,改进骨科治疗.

科学领域:

整形外科整形外科整形外科
再生医学是一种再生医学.
生物技术是生物技术.

背景情况:

与骨相关的疾病是一个日益严重的全球健康问题.
介酶干细胞衍生的细胞外囊泡 (MSC-EVs) 是具有治疗潜力的天然纳米粒子.
MSC-EV具有有利的特性,如生物相容性和药物携带能力.

研究的目的:

审查MSC-EVs调节骨代谢和血管性的机制.
探索MSC-EVs在骨疾病中的治疗应用,包括骨关节炎,类风湿性关节炎,骨质疏松症和骨肉瘤.
讨论工程MSC-EVs在增强骨准和临床翻译方面的作用.

主要方法:

关于MSC-EVs和骨病的综合文献综述研究.
对MSC-EV货物分子 (miRNAs, lncRNAs) 和它们在骨健康中的作用进行分析.
检查工程策略,以提高MSC-EV的有效性和定位.

主要成果:

MSC-EV有效地提供治疗性生物分子,影响骨代谢和血管化.
工程MSC-EV展示了增强的骨定位能力,减少了非目标效应.
MSC-EVs在各种骨病理中显示出显著的治疗前景.

结论:

由于其固有的特性和载荷,MSC-EVs是治疗骨相关疾病的有力治疗剂.
工程修改显著提高了MSC-EVs的临床翻译潜力.
在骨科应用中,MSC-EVs是一个有前途的无细胞治疗策略.

更多相关视频

Labeling of Extracellular Vesicles for Monitoring Migration and Uptake in Cartilage Explants

Labeling of Extracellular Vesicles for Monitoring Migration and Uptake in Cartilage Explants

Published on: October 4, 2021

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

The Extracellular Matrix

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...