在患有活跃结核病和结核病破坏肺部的患者中,与肺高血压相关的危险因素:一项回顾性研究
Weijian Liu1, Yuxiang Xu1, Liangzi Yang1
1Department of Pulmonary Medicine and Tuberculosis, The Third People's Hospital of Shenzhen, National Clinical Research Center for Infectious Disease, Southern University of Science and Technology, Shenzhen, China.
Scientific reports
|May 2, 2024
概括
肺高血压 (PH) 是结核病摧毁肺 (TDL) 的患者的一个风险. 晚年,D-二次数升高,头增高和严重的肺损伤预测TDL的活性肺结核 (PTB) 中PH的发展.
科学领域:
- 肺部病理学 肺部病理学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 肺结核破坏性肺 (TDL) 是由肺结核 (TB) 引起的严重慢性肺病.
- 肺高血压 (PH) 是肺部疾病的严重并发症,包括TDL,与高死亡率相关.
- 在TDL患者中确定PH的风险因素对于早期干预和改善结果至关重要.
研究的目的:
- 在被诊断为TDL和活性肺结核 (PTB) 的患者中研究与肺高血压 (PH) 相关的危险因素.
主要方法:
- 对237名TDL和活跃PTB患者的医疗记录的回顾性审查.
- 心声图被用来诊断PH.
- 为了确定风险因素,进行了单变量和多变量逻辑回归分析.
主要成果:
- 在TDL患者中,PH的显著危险因素包括晚年,呼吸不全,D-二次体升高,头 (PaCO2),肺叶损坏的数量,支气管切开和慢性肺炎.
- 一个结合年龄,D-二分体,PaCO2和被破坏的肺叶数量的预测模型实现了PH的80.6%的预测值.
- 该模型在PH预测方面显示了76.6%的灵敏度和73.2%的特异性.
结论:
- 晚年,升高的D-二次体,高头和广泛的肺损伤与TDL活跃PTB患者的PH有很强的相关性.
- 结合这些因素的预测模型可能有助于识别患PH高风险的患者.
- 在TDL患者中早期识别和管理PH对于降低死亡率至关重要.
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