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Updated: Jun 27, 2025

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协调化基因表达定义了跨组织的巨细胞子集

Xin Li1, Arlind B Mara1, Shawn C Musial1

  • 1Department of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, NH, USA.

Nature immunology
|May 2, 2024
PubMed
概括

间位性巨细胞 (IMs) 显示出由化学激素表达定义的多样化子集. 削弱特定的IMs减少了炎症细胞的招募和三级淋巴细胞结构的形成,揭示了它们在免疫调节中的关键作用.

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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