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与患有冠状动脉动脉网的受试者相比,患有冠状动脉动脉样硬化的受试者表现出促血栓动力学

Retta El Sayed^1,2, Carissa J Lucas¹, Hannah L Cebull²

¹Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, 1364 Clifton Rd, Atlanta, GA, 30322, USA.

Scientific reports

|May 2, 2024

概括

动脉网络 (CaW) 导致异常的血液流动,增加中风风险. 这些非动脉样硬化投射会导致流动静止和低剪切率,与轻度动脉样硬化或健康动脉不同.

科学领域:

血管外科血管外科
生物医学工程生物医学工程
神经学神经学

背景情况:

Carotid 动脉网络 (CaW) 是非动脉样硬化的光线投影,与年轻患者的密码性中风有关.
了解CaW对血液动力学的影响对于评估血块形成和中风风险至关重要.

研究的目的:

为了研究和比较患者特异性血液动力学在动脉分叉与CaW,轻度动脉样硬化,和健康的对照.
在CaW患者中确定与血管功能障碍和血栓形成相关的血液动力学参数.

主要方法:

计算流体动力学 (CFD) 模拟使用患者特定的计算机断层扫描血管学几何学.
从二维相位对比MRI扫描得出的入口边界条件.
血液动力学参数的分析,包括切割速率,振荡切割指数 (OSI),低速度和流量静止.

主要成果:

动脉网 (CaW) 与明显更大的低剪速,高OSI,低速度和流动静止的区域有关.
这些异常的血液动力学指标在CaW患者中比在轻度动脉样硬化或健康分叉患者中更明显.
这些发现突出了CaW引起的明显的血液动力学变化.

结论:

CaW显著扰乱了动脉分支中的正常血液动力学.
在CaW中发现的血液动力学异常与凝块形成和血管功能障碍有关.
血液动力学评估可以作为一个有价值的工具来评估中风风险在患有动脉网络的患者.

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