肌肉质量作为急性缺血性中风患者应激反应的修饰剂
Ethem Murat Arsava1, Levent Gungor2, Hadiye Sirin3
1Department of Neurology, Faculty of Medicine, Hacettepe University, 06230, Altindag, Ankara, Turkey. arsavaem@hotmail.com.
Scientific reports
|May 2, 2024
概括
在中风后,下骨肌指数 (SMI) 与炎症反应加剧相关,由中性粒细胞与淋巴细胞比率 (NLR) 的增加表明. 这表明肌肉质量与身体中风后的压力反应有关.
科学领域:
- 神经学 神经学
- 炎症研究 炎症研究
- 麻症研究研究 麻症研究
背景情况:
- 脑卒中诱导全身炎症反应,特别是在患有并发症的老年患者中.
- 麻症,或肌肉质量低,在中风幸存者中普遍存在,并与炎症有关.
- 中性粒细胞与淋巴细胞的比率 (NLR) 是炎症的生物标志物.
研究的目的:
- 调查急性缺血性中风后NLR和骨肌肉质量变化之间的关系.
- 为了确定肌肉消耗和中风后炎症状态之间的潜在联系.
主要方法:
- 102名急性缺血性中风患者的前性队列研究 (MASS-TR).
- 骨肌指数 (SMI) 是从入院CT扫描时的L3骨肌区域计算的.
- 中性粒细胞与淋巴细胞的比率 (NLR) 在入院和随访时测量.
主要成果:
- 在SMI和入院NLR之间没有发现显著的相关性.
- 在SMI和随访NLR之间观察到显著的反相关性 (r = -0.26;P = 0.007).
- 在多变量分析中,较低的SMI独立地与更高的随访NLR水平相关 (P = 0.036).
结论:
- 骨肌肉质量与中风后的炎症应激反应相反.
- 较低的肌肉质量可能表明中风后更明显的全身炎症反应.
- 肌肉质量是影响中风后炎症动态的潜在新型因素.
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