生物衰老与糖尿病视网膜病变之间的关联
Haoxian Tang1,2, Nan Luo1,3, Xuan Zhang1,4
1Shantou University Medical College, Shantou, Guangdong, China.
Scientific reports
|May 2, 2024
概括
生物衰老,以生物年龄 (BA) 和表型年龄 (PA) 衡量,与糖尿病视网膜病变 (DR) 有显著的关联. 这些衰老指标比时间表年龄更有效地预测DR风险,突出了预防潜在的抗衰老干预措施.
科学领域:
- 眼科医生 眼科 眼科
- 老年学是一门学科.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病 (DM) 的一个重要并发症.
- 生物衰老对DR风险的影响尚未完全理解.
- 时间年龄 (CA) 可能无法完全捕捉与衰老相关的DR风险.
研究的目的:
- 研究生物衰老指标 (生物年龄 (BA) 和表型年龄 (PA)) 与糖尿病视网膜病变 (DR) 之间的关联.
- 将BA和PA的预测能力与DR风险的CA进行比较.
- 评估BA和PA在DR预测中的临床实用性.
主要方法:
- 利用了国家健康和营养调查 (2005-2008) 的数据.
- 从临床标志物计算BA和PA.
- 员工调查加权的多变量逻辑回归和受限制的立方线索用于分析.
- 使用接收器操作特征 (ROC) 曲线和决策曲线分析 (DCA) 评估模型性能.
主要成果:
- 生物年龄 (OR=1.12) 和表型年龄 (OR=1.11) 与DR有显著的关联,而时间年龄没有 (OR=1.01).
- 与CA相比,BA和PA对DR的预测能力和临床实用性优于CA.
- 结果在各个子组中一致,包括因胰岛素使用而调整的糖尿病患者.
结论:
- 生物衰老,如BA和PA所示,是糖尿病视网膜病变风险的更强的预测因素,而不是时间的年龄.
- BA和PA为DR风险评估提供了增强的临床实用性.
- 强调在DR预防策略和潜在的抗衰老干预中考虑生物衰老的重要性.
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