生物衰老与牙周炎之间的关联使用NHANES 2009-2014和孟德尔随机化
Sihong Li1, Chang Wen1, Xueying Bai1
1State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Scientific reports
|May 2, 2024
概括
生物衰老,而不是时间上的年龄,与牙周炎风险增加有关. 加速衰老措施显示,患牙周炎的几率更高,尽管因果关系没有被证明.
科学领域:
- 老年学是一门学科.
- 牙周病学 牙周病学
- 流行病学 流行病学
背景情况:
- 老龄化是牙周炎的已知危险因素.
- 生物衰老提供了一个比时间年龄更精确的功能状态衡量标准.
- 了解生物衰老与牙周炎之间的联系对于公共卫生至关重要.
研究的目的:
- 研究生物衰老与牙周炎之间的关联.
- 通过多种生物年龄指标来探索这种关系.
- 确定加速生物衰老是否对牙周炎风险产生因果影响.
主要方法:
- 从国家健康和营养检查调查 (2009-2014) 中对9803名参与者的横截面分析.
- 计算了三种生物年龄 (克莱梅拉 - 杜巴尔方法,PhenoAge,恒温失调) 和两种加速衰老措施 (BioAgeAccel,PhenoAgeAccel).
- 使用了后勤回归,受限立方线回归和门德尔随机化分析.
主要成果:
- 在较高的生物年龄,加速衰老和牙周炎之间发现了显著的关联.
- 增加的生物年龄与更高的牙周炎风险相关 (每年15%的HD,3%的KDM,4%的PhenoAge).
- 加快衰老 (BioAgeAccel/PhenoAgeAccel) 增加了牙周炎的可能性20-37%;然而,门德尔随机化没有显示出因果关系.
结论:
- 生物衰老与牙周炎的风险增加有关.
- 针对衰老路径的预防策略可能会降低老年人牙周炎风险.
- 虽然相关,加速的生物衰老似乎不是牙周炎的直接原因.
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