在血液学服务中确定与药物有关的问题:一项前性干预研究
Aslınur Albayrak1, Demircan Özbalcı2
1Department of Clinical Pharmacy, Faculty of Pharmacy, Suleyman Demirel University, Isparta, Türkiye. aslinuralbayrak@sdu.edu.tr.
BMC cancer
|May 2, 2024
概括
与药物相关的问题 (DRPs) 影响了近一半的血液病患者,多药和更长时间住院增加了风险. 临床药剂师对于在多学科团队中识别和预防这些问题至关重要.
科学领域:
- 临床药房 临床药房
- 血液学 血液学 血液学
- 药物监督 药物监督 药物监督
背景情况:
- 血液性恶性瘤患者经常接受复杂的多药疗法,增加与药物相关问题的风险 (DRPs).
- 确定DRP对于优化治疗目标和预防住院血液病患者的不良事件至关重要.
- 这项研究的重点是确定土耳其大学医院的血液学服务中的DRP.
研究的目的:
- 在血液学服务中住院的患者中识别与药物相关的问题 (DRPs).
- 评估在多学科团队中临床药剂师在检测DRPs中的作用.
- 在这个患者群体中分析与DRP相关的风险因素.
主要方法:
- 从2022年12月到2023年5月在血液学服务中进行的前性研究.
- 使用欧洲医药护理网络 (PCNE) 9.1 土耳其版本进行DRP评估.
- 包括140名患者,分析人口统计,临床和药物数据.
主要成果:
- 几乎一半 (49.3%) 的患者至少经历过一次DRP,总计152个DRPs.
- 较高的DRP发病率与年龄较大,住院时间较长,特定的白血病类型,并发症和多药性有关.
- 多药性药物显著增加了DRP的可能性 (OR 7.921),每增加5天的住院时间都会增加DRP的风险 (OR 1.476).
- 药物不良事件是最常见的DRP (96.7%),主要是由不适当的药物选择 (94.7%) 引起的.
结论:
- 临床药剂师在多学科团队中发挥着至关重要的作用,在血液学服务中识别和预防DRPs.
- 对DRP的早期检测和干预对于改善血液学患者的结果至关重要.
- 针对多药和优化药物选择的战略对于缓解DRPs至关重要.
相关概念视频
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
125
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125
01:19Pharmacovigilance
829
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
829
01:23Drug Concentrations: Measurements
364
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
364