生物类似药和在免疫介导疾病中获得生物疗法
Rocío Vázquez-Sánchez1, Marco Navarro-Dávila2, Esther Ramírez Herráiz3
1Hospital Pharmacy Department, Getafe University Hospital, Getafe, Madrid, Spain.
Expert opinion on biological therapy
|May 2, 2024
概括
生物仿制药显著改善了对免疫媒介炎症疾病 (IMIDs) 的生物治疗的准入. 它们的可用性将治疗开始时间缩短了1.6年,提高了患者获得关键疗法的机会.
科学领域:
- 药物经济学 药物经济学
- 免疫学 免疫学 免疫学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 生物药物对免疫介导炎症性疾病 (IMIDs) 至关重要.
- 生物制剂的高成本需要优化效率.
- 生物类似药提供了具有成本效益的替代品,改善了治疗的可获得性.
研究的目的:
- 评估生物类似药物可用性对IMID患者生物疗法获取的影响.
- 在现实世界中分析生物疗法的可用性和启动时间.
主要方法:
- 在15家西班牙医院进行了回顾性观察性研究.
- 对267名IMID患者 (关节病,IBD,牛皮) 开始生物治疗的分析.
- 对原始药与生物类似药 (infliximab,etanercept,adalimumab) 的治疗开始时间的比较.
主要成果:
- 58.4%的患者开始使用生物类药物治疗.
- 生物药物可用性的平均时间为15.9个月 (生物类药物更短:11.8个月,而原始药物为20.0个月).
- 开始治疗的平均时间为7.7年 (生物类似药的时间较短:7.0年,而原始药的时间为8.6年).
结论:
- 生物相似的出现增强了市场竞争和医院采用.
- 生物仿制药显著改善了患者获得IMIDs生物治疗的机会.
- 对生物类似药物而言,使用时间缩短了1.6年.
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