超乳酸血是心力衰竭中运动能力降低的标志物,具有保存的喷射分数
Emilia Nan Tie1, Emil Wolsk2, Shane Nanayakkara1,3,4
1Department of Cardiology, Alfred Hospital, Melbourne, VIC, 3004, Australia.
ESC heart failure
|May 3, 2024
概括
由于氧气使用的变化,心力衰竭与保留喷射分数 (HFpEF) 导致运动能力降低,导致乳酸盐水平提高. 这种高乳糖血症可能表明血液动力学和代谢问题,表明治疗目标.
科学领域:
- 心脏病学 心脏病学
- 运动生理学 运动生理学
- 代谢研究研究 代谢研究
背景情况:
- 保存喷射分数 (HFpEF) 的心力衰竭呈现出复杂的中央和外周血液动力学和代谢变化.
- 在HFpEF中运动不耐受背后的精确机制仍然不完全理解.
- 了解这些因素对于开发有效的治疗方法至关重要.
研究的目的:
- 为了研究和比较运动期间的乳酸积累.
- 分析HFpEF患者对运动的中央血液动力学反应.
- 将这些反应与非心脏性呼吸不良 (NCD) 患者和健康志愿者的反应进行对比.
主要方法:
- 用右心导管测量混合静脉血液气体和乳酸盐水平.
- 测量是在休息状态和在症状有限的卧底运动期间进行的.
- 多变量分析确定了血液动力学/生化参数与运动能力之间的关系.
主要成果:
- 与健康志愿者相比,患有HFpEF的患者表现出较低的峰值工作量和减少的氧气输送.
- 与工作负荷相关的运动乳酸指数在HFpEF患者中明显高于NCD和健康组.
- 在HFpEF中,女性性别和慢性病是运动乳酸水平升高的预测因素.
结论:
- HFpEF与由于氧气利用能力受损而导致的运动能力下降有关.
- 这导致运动诱导的高乳糖血,反映了潜在的血液动力学和心脏代谢功能障碍.
- 运动期间的乳酸反应可以作为HFpEF管理中的生物标志物和治疗标.
相关概念视频
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
01:22Heart Failure Drugs: Diuretics
370
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
370