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社会环境对雄性灵长类动物HPG和HPA轴发育编程的影响

Ella R Brown¹, Lee T Gettler^2,3, Stacy Rosenbaum¹

¹Department of Anthropology, University of Michigan, Ann Arbor, Michigan, USA.

Developmental psychobiology

|May 3, 2024

概括

早期的社会环境在男性中显著塑造了下丘脑-垂体-淋巴腺 (HPG) 和下丘脑-垂体-上腺 (HPA) 轴的发展. 本综述探讨了社会线索如何影响男性HPG和HPA轴编程,包括表观遗传的影响.

科学领域:

进化生物学是进化的生物学.
神经内分泌学神经内分泌学
发育生物学是发展生物学.

背景情况:

发育可塑性允许表型在灵长类动物的长期生长期间适应环境线索.
垂体-垂体-腺 (HPG) 和垂体-垂体-上腺 (HPA) 轴是健康相关特征的关键调节器,对环境信号作出反应.
社会环境是HPG和HPA轴编程的关键线索,特别是在像人类这样的社会物种中.

研究的目的:

审查社会环境对HPG和HPA轴编程对人类和非人类灵长类动物男性发育的影响.
识别早期社会经验影响的关于男性特异性HPG和HPA轴编程的知识差距.
探索表观遗传机制在调解这些社会效应方面的潜在作用.

主要方法:

文献综述综合了现有关于社会环境对灵长类HPG和HPA轴的影响的研究.
专注于检查男性发育的研究,解决当前文献中代表性不足的问题.
包括调查与社会编程相关的表观遗传修饰的研究.

主要成果:

早期的社会环境显然会影响两性中HPG和HPA轴的发育,尽管对男性的研究有限.
由于开发和研究方面的挑战,在理解男性特有的HPG轴编程和HPA/HPG接口方面存在重大差距.
表观遗传机制正在成为社会环境对这些神经内分泌轴的影响的重要调解者.

结论:

早期的社会环境对于男性的HPG和HPA轴的编程至关重要,影响性发展和成人策略.
需要进一步的研究,以充分阐明男性中这些轴的社会编程背后的机制,包括表观遗传因素.
解决男性发育的研究缺口对于全面了解对灵长类神经内分泌系统的社会影响至关重要.

关键词:

发展规划是指发展规划.下丘脑垂体上腺轴下丘脑海 pituitary阴腺轴雄性灵长类动物中的雄性灵长类动物.社会环境社会环境社会环境

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