减肥药物在儿科代谢功能障碍相关的脂肪性肝病中的利用和前景
Mohit Kehar1, Samar H Ibrahim2, Charina M Ramirez3
1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
概括
儿童代谢功能障碍相关的脂肪性肝病 (MASLD) 对像GLP-1RA这样的减肥药物越来越感兴趣. 然而,指导方针的挑战和副作用的担忧凸显出需要更好的教育和更清晰的临床途径.
科学领域:
- 儿科胃肠病学和肝病学
- 代谢障碍 代谢障碍 代谢障碍
- 药物治疗 药物治疗
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是儿童日益严重的全球健康问题.
- 目前的管理依赖于生活方式干预,经常面临难以实现持续减肥的困难.
研究的目的:
- 调查儿科专家关于在MASLD管理中使用减肥药物的当前观点和实践.
- 确定与儿科MASLD药物治疗相关的障碍和教育需求.
主要方法:
- 在166名儿科胃肠病学家和肝病学家中进行了一项国际调查.
- 该调查评估了对减肥药物的认识,考虑和使用情况,包括特定的药物类别和感知到的挑战.
主要成果:
- 很大一部分从业者 (38%) 正在考虑或使用减肥药物,特别感兴趣的是葡萄糖类-1受体激活剂.
- 临床医生经常将患者转诊给专家,这表明在承认药物治疗的作用和直接处方之间存在潜在的差距.
- 缺乏确定的指导方针和关于副作用的不确定性被确定为关键挑战.
- 超过90%的受访者表达了对该主题进一步教育的强烈兴趣.
结论:
- 对于儿科MASLD的药物治疗有相当大的兴趣,特别是像GLP-1RA这样的药物.
- 通过制定指南和全面教育来应对挑战,对于将减肥药物纳入临床实践至关重要.
- 需要改善教育资源和更明确的指导,以支持临床医生有效管理儿科MASLD.
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