产后外周止痛与肠道微生物群之间的关联:一项前性队列研究
Jing-Hui Hu1,2, Jie Sheng3, Hui-Min Guo3
1Departments of Anesthesiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Heliyon
|May 3, 2024
概括
产后外周止痛 (LEA) 改变了母亲和新生儿肠道微生物群的组成. 需要进一步的研究来了解肠道细菌中这些变化的临床影响.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 胃肠病学 胃肠病学
背景情况:
- 产后外周止痛 (LEA) 是分娩期间常见的疼痛管理技术.
- 对LEA对母亲和新生儿肠道微生物群的影响仍然是积极研究的领域.
- 了解这些影响对于评估潜在的长期健康影响至关重要.
研究的目的:
- 为了研究分娩外周止痛和母亲和新生儿的肠道微生物群概况之间的关联.
- 在母体和新生儿样本中识别受LEA影响的特定细菌种群.
主要方法:
- 一项前性队列研究,涉及45名母婴双胞胎.
- 参与者被分为LEA和对照组.
- 使用16S rRNA基因测序和统计建模进行肠道微生物群分析.
主要成果:
- 在LEA和对照组之间观察到肠道微生物群多样性的显著变化 (α和β).
- 在母亲中,LEA与*R. ilealis*正相关.
- LEA与*A. pittii*,*P. aeruginosa*,*S. maltophilia*在母亲身上和*Muribaculaceae*在新生儿身上负相关.
结论:
- 产后外周止痛与母亲和新生儿肠道微生物群的明显变化有关.
- 需要进一步的研究来阐明LEA诱导的微生物群变化的临床意义和潜在机制.
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