针治疗多发性骨髓瘤外围神经病变:一个系统性审查
Chunyi Lyu1, Hongyan Xiao1, Xuewei Yin2
1First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, People's Republic of China.
Journal of pain research
|May 3, 2024
概括
针在治疗多发性骨髓瘤患者的与药物相关的外围神经病变方面显示出有前途,有效减少疼痛. 然而,由于治疗方法的多样性,需要更多的研究来证实它的有效性.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 综合医学是一个整体医学.
背景情况:
- 周围神经病变 (PN) 是多发性骨髓瘤 (MM) 的常见并发症,影响患者的生活质量.
- 目前针对多发性骨髓瘤外围神经病变 (MMPN) 的治疗方法缺乏明确的最佳策略.
- 正在探索针作为MMPN的潜在治疗选择.
研究的目的:
- 系统地审查和分析有关针治疗MMPN的有效性和安全性的现有文献.
- 评估针对MMPN患者疼痛和神经功能的影响.
主要方法:
- 在主要数据库 (PubMed,科学网,MEDLINE,Cochrane图书馆,Embase) 进行了全面的文献搜索,截至2023年11月1日.
- 这项分析包括了5项涉及97名药物相关PN患者的研究.
- 关于疼痛尺度 (VAS,NPS,BPI-SF,FACT/GOG-Ntx) 和神经传导速度 (NCV) 的数据被提取和分析.
主要成果:
- 针治疗在多个经过验证的尺度上导致疼痛得分的持续减少.
- 经常使用的针点包括ST36,LI4,SP6和EX-LE-10.
- 在神经传导速度 (NCV) 测试中观察到相互矛盾的结果,没有报告严重的不良事件.
结论:
- 针似乎是安全和有益的缓解与药物相关的MMPN的疼痛.
- 在MM中缺乏与疾病相关的PN的针研究.
- 由于治疗方案的异质性,需要进一步的高质量研究来确定最终的疗效.
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