鉴定2型糖尿病和COVID-19之间的共同基因和通路
Ya Wang1,2, Kai Li3, Shuangyang Mo4
1Gastroenterology Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Frontiers in genetics
|May 3, 2024
概括
这项研究确定了2型糖尿病 (T2DM) 和COVID-19中常见的五个关键基因,揭示了这些疾病之间的潜在分子联系. 这些发现为T2DM和COVID-19背后的共享机制提供了新的见解.
科学领域:
- 基因组学和生物信息学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 2型糖尿病 (T2DM) 和2019年冠状病毒病 (COVID-19) 具有严重疾病的高发病率.
- COVID-19可能导致血糖水平变化和新发糖尿病,但潜在的分子机制尚不清楚.
研究的目的:
- 为了确定T2DM和COVID-19之间共享的共同基因和分子途径.
- 探索两种疾病的潜在诊断生物标志物和治疗点.
主要方法:
- 对公共基因表达总 (GEO) 数据集 (GSE95849,GSE164805) 的分析,以识别差异表达基因 (DEG).
- 基因本体学 (GO) 和基因和基因组 (KEGG) 丰富分析的京都百科全书.
- 蛋白与蛋白相互作用 (PPI) 和miRNA-转录因子-mRNA调节网络的构建.
- 使用独立数据集进行验证 (GSE213313,GSE15932).
主要成果:
- 确定了81种上调和140种下调的DEGs,它们与T2DM和COVID-19共同存在.
- 富化分析将DEG与酸盐代谢,线粒细胞核分裂和T细胞/淋巴细胞共同刺激联系起来.
- 五个基因 (DHX15,USP14,COPS3,TYK2,RIOK2) 在T2DM和COVID-19中都表现出高的诊断准确性.
- 构建了一个涉及关键基因,转录因子和microRNAs的调控网络.
结论:
- 确定了五个共同的特征基因 (DHX15,USP14,COPS3,TYK2,RIOK2) 链接T2DM和COVID-19.
- 这些基因及其相关途径为连接这些疾病的分子机制提供了新的见解.
- 这些基因作为诊断生物标志物或治疗点的潜力需要进一步调查.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Pathophysiology of Diabetes
922
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
922
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Single Nucleotide Polymorphisms-SNPs
15.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Overview of Carbohydrate Metabolism
964
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
964


