基于巨细胞的药物输送:关键挑战和战略
Qian Guo1, Zhong-Ming Qian2,3
1Laboratory of Drug Delivery, School of Medicine, Shanghai University, 99 Shangda Road, Shanghai, 200444, China.
Bioactive materials
|May 3, 2024
概括
巨细胞是多功能免疫细胞,有望成为疾病的药物载体. 本综述详细介绍了在治疗和临床转化中有效使用它们的挑战和策略.
科学领域:
- 免疫学 免疫学 免疫学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 巨细胞是天然的免疫和抗原呈现细胞,具有有利于药物输送的固有特性,包括生物相容性,长循环,炎症指导和细胞化.
- 它们的可塑性和极化能力使它们适合治疗炎症性疾病和瘤.
- 最近的进展突出了基于巨细胞的药物输送,但重大挑战阻碍了治疗疗效和临床应用.
研究的目的:
- 识别和分析利用巨细胞用于药物输送的主要挑战.
- 讨论克服这些障碍的战略和见解.
- 为基于巨细胞的治疗方法的临床转化和生产提供视角.
主要方法:
- 对基于巨细胞的药物输送现有文献的综述.
- 分析挑战,包括巨细胞来源选择,药物加载,表型维护和药物释放动力学.
- 探索潜在的解决方案和未来的方向.
主要成果:
- 确定的主要挑战包括:选择适当的巨源,有效和稳定的药物加载方法,保持所需的巨表型,控制药物迁移和释放到目标部位.
- 应对这些挑战的策略包括优化细胞采购,开发先进的加载技术,采用极化协议和工程控制释放机制.
- 该审查强调需要强大的方法来确保治疗疗效和安全.
结论:
- 克服已确定的挑战对于推进基于巨细胞的药物输送系统至关重要.
- 对细胞来源,药物加载,表型控制和向释放的进一步研究是必要的.
- 解决这些问题将为成功的临床转化和生产这些新型治疗方法铺平道路.
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