外围表观基因组预测白质体积取决于发育阶段:一个ECHO研究
Sophie Spencer1, Samantha A Harker1, Fatoumata Barry2
1Arizona State University.
Research square
|May 3, 2024
概括
髓基因的外围DNA甲基化预测了儿童的白质量. 这种表观遗传标记是表观遗传标记.
科学领域:
- 神经科学和表观遗传学:研究DNA甲基化,大脑发育和白质结构之间的相互作用.
背景情况:
- 人们对表观遗传过程越来越感兴趣,例如DNA甲基化作为大脑疾病的生物标志物.
- 关于DNA甲基化与个体大脑结构和功能变异的相关性,存在重大知识差距.
- 我们对这些表观遗传关系在关键发育时期如何变化的理解有限.
结论:
- 与髓相关基因的外围DNA甲基化作为儿童白质体积的预测标记.
- 发育阶段显著影响DNA甲基化-白质体积关系.
- 外围表观遗传模式可以代表环境因素和疾病对白质物的影响.
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