休息心率的时间变化对未来糖尿病相关结果的影响
Lu Gao1, Guo-Hong Wang1, Gang Wan2
1Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Frontiers in endocrinology
|May 3, 2024
概括
静止心率 (RHR) 的长期变化预测了2型糖尿病 (T2DM) 的临床事件. 显著的RHR增加会增加心血管事件和死亡的风险,而中度降低则提供了保护.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 休息心率 (RHR) 是一个关键的心血管指标.
- 之前的研究主要在一个时间点分析了RHR.
- 在2型糖尿病 (T2DM) 中的长期RHR动态仍未得到充分研究.
研究的目的:
- 研究长期RHR变化对T2DM患者临床结果的影响.
- 评估十年来RHR趋势和变化的预测价值.
主要方法:
- 这是一项为期十年的对2513名T2DM参与者的队列研究.
- 两阶段的随访分析RHR变化和临床事件.
- 考克斯比例危险模型用于确定危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 基线RHR和长期事件之间没有显著的相关性.
- 随着RHR的大幅增加,心血管事件 (HR=3.40) 和全因死亡 (HR=3.22) 的风险显著增加.
- 适度的RHR降低与所有死因 (HR=0.55) 和主要不良心脏和脑血管事件 (MACCE) (HR=0.51) 的风险降低有关.
- 增加RHR趋势 (正常至高) 预测复合终点事件 (HR=1.64) 和脑血管事件 (HR=2.82).
结论:
- 长期的RHR变化是T2DM临床事件的显著预测因素.
- 升高的RHR趋势表明心血管和脑血管不良结果的风险增加.
- 监测RHR动态对于糖尿病人群的风险分层和风险管理至关重要.
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