急性压力通过异常的前额叶皮层激活在高特征反动物中损害了故意的记忆抑制
Jixin Long1,2,3, Lanxin Peng1,2, Qian Li1,2
1Laboratory of Cognitive Control and Brain Healthy, Department of Psychology, School of Public Health, Southern Medical University, Guangzhou, PR China.
概括
高特征的反动物在压力下表现出受损的记忆抑制,这与背前额叶皮质和上回形中大脑活动的改变有关. 这表明在与压力相关的障碍中干预的潜在目标.
科学领域:
- 认知神经科学 认知神经科学
- 心理学 心理学 心理学
背景情况:
- 心理特征的个体差异调节压力对记忆抑制的影响.
- 高特征反动物 (HTR) 患有与压力相关的疾病的风险增加,但在急性压力下他们的记忆抑制并未得到充分理解.
研究的目的:
- 研究急性压力对高特征反动物 (HTR) 和低特征反动物 (LTR) 的故意记忆抑制的影响.
- 探索神经相关性,包括大脑激活和功能连接,与压力下的HTR中记忆抑制相关.
主要方法:
- 55名健康的大学生被归类为HTR或LTR.
- 一个思考/不思考的任务被用来评估压力诱导后的记忆抑制.
- 用功能近红外光谱 (fNIRS) 和心理生理相互作用分析来检查神经活动和连接性.
主要成果:
- 与压力下的LTR相比,HTR表现出较差的记忆抑制性能.
- 在记忆抑制过程中,HTR表现出异常激活和在背前额皮层 (DLPFC) 和上旋 (STG) 中功能连接的改变.
- DLPFC和STG之间的任务调节功能连接调解了HTR中记忆抑制性能和状态反之间的关系.
结论:
- 急性压力会影响HTR中的故意记忆抑制,与不同的神经机制有关.
- 研究结果为开发预防策略和早期干预提供了见解,用于高特征反的人群中与压力相关的疾病.
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