在老年人中,短期血压变化和大脑功能网络连接性
Isabel J Sible1, Jung Yun Jang2, Anna E Blanken3,4
1Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA.
Neuroimage. Reports
|May 3, 2024
概括
老年人血压变化升高与大脑默认网络中的功能连接性降低有关. 这一发现表明血压变化可能是神经血管功能障碍和阿尔茨海默病的早期风险因素.
科学领域:
- 神经科学是一个神经科学.
- 心血管科学 心血管科学
- 老年学是指老年学的学科.
背景情况:
- 血压变化 (BPV) 越来越多地与脑血管疾病和阿尔茨海默氏症有关.
- 升高的BPV可能会影响脑血管反应和大脑网络连接.
- BPV与功能网络连接之间的关系尚不清楚.
研究的目的:
- 研究与衰老和阿尔茨海默病相关的大脑网络中节拍血压变化和功能连接之间的关联.
主要方法:
- 53名没有痴呆症或中风的社区老年人接受了持续的血压监测和休息状态fMRI.
- 血压变化被计算为独立于平均值的变化.
- 使用静止状态fMRI对默认,突出,背部注意力,前端-parietal和语言网络进行功能连接的评估.
主要成果:
- 较高的短期血压变化与默认网络中的功能连接性较低有显著的相关性 (心缩:β = -0.30,p = .04).
- 在BPV和其他网络的连接性之间没有发现任何显著的关联.
- 在任何网络中,平均血压和功能连接之间没有发现显著的关联.
结论:
- 患有短期BPV升高的老年人显示在默认网络中休息状态功能连接性降低.
- 研究结果支持BPV在神经血管功能障碍和阿尔茨海默病中的作用.
- BPV可能是与阿尔茨海默病相关的神经血管功能障碍的未研究的早期血管风险因素.
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