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氧化生物标志物 - - 一个有效的工具来诊断COVID-19患者和康复者

Blanka Wolszczak-Biedrzycka¹, Justyna Dorf², Joanna Matowicka-Karna²

¹Department of Psychology and Sociology of Health and Public Health, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Journal of inflammation research

|May 3, 2024

概括

COVID-19 感染会破坏身体的氧化还原平衡,增加氧化应激和损伤. 先进的糖化终端产品 (AGEs) 显示出潜在的可靠生物标志物,用于诊断COVID-19及其恢复阶段.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
临床医学临床医学

背景情况:

COVID-19 (冠状病毒疾病2019) 与增加反应性氧物种 (ROS) 生产有关.
这种氧化应激,加上抗氧化剂防御受损,导致细胞损伤,包括蛋白质和脂质过氧化.

研究的目的:

在COVID-19患者,康复者和健康个体中评估酶和非酶抗氧化剂.
评估蛋白质和脂质过氧化的氧化还原潜力和标记物.
确定这些参数在COVID-19中的诊断效用.

主要方法:

该研究包括218名COVID-19患者,69名康复者和48名健康对照.
用色度测定和光谱测定分析了血清/血样本.
测量的关键参数包括谷氨缩小酶 (GR) 活性,总抗氧化能力 (TAC),先进的糖化终产物 (AGEs),先进的氧化蛋白产物 (AOPP),4-氨 (4-HNE) 和甲 (MDA).

主要成果:

与康复者和对照人群相比,COVID-19患者呈现出更高的GR活性和更低的TAC.
与对照组相比,在COVID-19患者和康复者中观察到高水平的AGE,AOPP,4-HNE和MDA.
先进的糖化终端产品 (AGEs) 在区分COVID-19患者和康复者与健康受试者方面表现出高的诊断准确性 (AUC>0.99).

结论:

SARS-CoV-2 感染显著破坏了氧化还原平衡,增加了氧化损伤.
先进的糖化终产品 (AGEs) 被确定为诊断COVID-19和监测恢复的有希望的生物标志物.

关键词:

在 COVID-19 疫情中,在SARS CoV-2病毒.抗氧化剂抗氧化剂是一种抗氧化剂.氧化应激是一种氧化应激.氧化还原生物标志物

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