免疫检查点抑制剂在晚期和复发/耐药霍奇金淋巴瘤:当前的应用和未来的前景
Charles J Milrod1, Ari Pelcovits1, Thomas A Ollila1
1Department of Hematology/Oncology, Brown University, Providence, RI, United States.
Frontiers in oncology
|May 3, 2024
概括
免疫检查点抑制剂 (ICI) 正在改变经典的霍奇金淋巴瘤 (cHL) 治疗. 需要新的策略来评估治疗反应,因为PET扫描可能与ICI不那么可靠,但循环瘤DNA (ctDNA) 显示出希望.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 经典霍奇金淋巴瘤 (cHL) 治疗正在使用免疫检查点抑制剂 (ICI) 发展.
- 集成疗法集成到一线和复发性/耐火性 (R/R) cHL疗法中.
- 这种整合给传统治疗反应评估带来了挑战.
研究的目的:
- 审查ICI在cHL治疗中的影响.
- 为了探索因ICI诱导的炎症而导致的反应评估的挑战.
- 突出循环瘤DNA (ctDNA) 在响应适应治疗中的潜力.
主要方法:
- 对cHL中ICI的当前文献的审查.
- 在ICI时代对治疗反应评估策略的分析.
- 作为预测生物标志物的循环瘤DNA (ctDNA) 的评估.
主要成果:
- ICI-化疗组合在一线和R/R cHL中表现有前途.
- 佩特扫描阳性率可能更高,并且在某些ICI疗法 (例如,布罗利祖马布-AVD) 中的预测能力较低.
- 循环瘤DNA (ctDNA) 成为补充或替代PET扫描进行反应评估的潜在工具.
结论:
- ICI正在改变cHL治疗模式,提供更好的结果.
- 传统的反应评估方法,如PET扫描,在ICI时代需要重新评估.
- ctDNA具有显著的潜力,可以改进响应适应的策略,并提高cHL的治疗精度.
相关概念视频
Tumor Immunotherapy
520
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
520
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Cytotoxic T Cells-mediated Immune Response
903
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
903


