延迟第一次性交时的年龄可以防止口腔癌:一项孟德尔的随机化研究
Ting Sun1, Xin He2, Xing Chen3,4
1Department of Oncology, Guangyuan Central Hospital, Guangyuan, China.
Frontiers in oncology
|May 3, 2024
概括
延迟第一次性交可能会降低患口腔癌 (OCC) 的风险. 这项研究发现了一种因果关系,表明公共卫生教育后期的性初次可能是有保护作用的.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 口腔癌 (OCC) 在全球范围内对健康造成重大负担.
- 了解OCC可修改的风险因素对于预防策略至关重要.
研究的目的:
- 调查第一次性交时的年龄与患口腔癌的风险之间的潜在因果关系.
- 为了确定延迟性开始是否会影响OCC风险.
主要方法:
- 采用两个样本的门德尔随机化 (MR) 分析,使用英国生物库的遗传数据来确定第一次性交时的年龄作为工具变量.
- 作为结果,利用了北美口腔癌全基因组关联研究的总结统计数据.
- 应用了反向方差加权 (初级),MR-Egger和加权中位数方法,并进行了 robustness 检查,包括 Cochran Q,MR-Egger 拦截,MR-PRESSO 和 leave-one-out 分析.
主要成果:
- 在第一次性交时的早期年龄和口腔癌的风险增加之间显示出显著的积极因果关系 (p = 0.0002).
- 延迟第一次性交的年龄与口腔癌的风险降低有关 (β = -1.013).
- 二次分析和强度评估证实了延迟性开始对OCC的保护作用.
结论:
- 延迟第一次性交的年龄与口腔癌的风险降低有因果关系.
- 促进延迟性开始的公共卫生倡议可以作为预防口腔癌的保护措施.
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